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MECHANOCHEMICAL TECHNOLOGY FOR DEVELOPMENT OF BENZIMIDAZOLE BASED ANTHELMINTIC AGENTS
Halikov S.S., Chistyachenko Yu.S., Dushkin A.V., Meteleva E.S., Archipov I.A., Varlamova A.I., Glamazdin I.I., Danilevskaya N.V.
A.N. Nesmeyanov Institute of Organoelement Compounds RAS, Institute of Solid State Chemistry and Mechanochemistry SB RAS, All-Russian K.I. Skryabin Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants RAS, K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology.
Summary
One showed the perspectives of mechanochemical modification of number of benzimidazole substances with water soluble polymers. The obtained supramolecular complex of “guest-host” type exerted the high efficacy on laboratory models of helminthoses. The agent efficacies were confirmed on sheep spontaneously infected by gastrointestinal nematodes with dose reduction by 9-10 times.
© 2015 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) and the Agreement of 12.06.2014 (CABI.org / Human Sciences section).