DOI: 10.12737/11780
Article history:
Received 11.02.2015
Accepted 14.03.2015
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Avertel tolerance in dogs tested under subchronic conditions
Novik T. S.1, Yastreb V. B.1, Chukina S. I.1,21All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin, 117218 Russia, 28
B. Cheremushkinskaya St,
2Biological Science Center «Pharmbiomed Ltd.»
e-mail: novik@vniigis.ru, yastreb@vniigis.ru
Abstract
Materials and methods
The drug was injected to dogs daily within 7 days with 24-hour interval subconsciously at a therapeutic dose of 1 ml/kg or 0,5 mg/kg of aversectine C1 and 5 mg/kg of praziquantel and at a triple dose (0,3 ml/kg – 1,5 mg/kg aversectine C1 and 15 mg/kg of praziquantel).
Results and discussion.
Before injection and 1,5 and 10 days after the last injection the blood samples were collected to determine the hematological and biochemical parameters.
The results of observation of general health status and behavior of dogs as well as the clinical, hematological and biochemical parameters serve as evidence of good tolerance of preparation used at the recommended therapeutic and increased doses.
Keywords: dogs, Avertel, hematological and biochemical data.
References
1. Yastreb V. B., Novik T. S., Valieva Zh. M. Efficacy of Aversect plus at echinococcosis and other taeniidoses in dogs. Mater. dokl. nauch. konf. Vseros. o-va gel'mintol. RAN «Teorija i praktika bor'by s parazitarnymi boleznjami». [Proceedings of scient. conf. «Theory and practice of struggle against parasitic diseases»]. Moscow, 2012, pp. 472-473.
2. Yastreb V. B., Novik T. S., Valieva Zh. M. Efficacy of Aversect plus at cestodosis and nematodosis in dogs and cats. Ros. parazitol. Zhurnal [Russian Journal of Parasitology], 2012, no. 3, pp. 121–124.
3. Yastreb V. B. Efficacy of Aversect plus used against ectoparasites in dogs and cats. Mater. dokl. nauch. konf. Vseros. o-va gel'mintol. RAN «Teorija i praktika bor'by s parazitarnymi boleznjami».[Proceedings of scient. conf. «Theory and practice of struggle against parasitic diseases»]. Moscow, 2013, pp. 447-449.
4. Yastreb V. B., Novik T. S. Estimation of efficacy of Avertel used against endo- and ectoparasites in dogs and cats. Ros. parazitol. Zhurnal [Russian Journal of Parasitology], 2014, no. 4, pp. 105–113.
© 2015 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI)) and the Agreemnt of 12/06/2014 (CABI org / Human Sciences section)