Methodological guidelines for application of immunomodulatory agents in combination therapy of helminthosis

Russian Journal of Parasitology
DOI: 10.12737/11782
Article history:
Received 12.05.2014
Accepted 14.01.2015
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Methodological guidelines for application of immunomodulatory agents in combination therapy of helminthosis



O. I. Mamykova
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin, 117218, Moscow, 28 B. Cheremushkinskaya str., e-mail: mamikova@vniigis.ru
(Approved by Section «Infectious diseases in animals» of Division of Veterinary Medicine of Russian Academy of Agricultural Sciences on 22nd of March, 2012, Protocol No 1)

Abstract

Methodological guidelines for application of immunomodulatory agents in combination therapy of helminthosis have been developed. The list of immunomodulatory drugs recommended for combination therapy of animal helminthosis includes T-activin, Ribotan, Ronkoleikin, Polyoxidonium. The isolated drug application reveals the selective mechanism of their immune-biological effects. T-activin directly affects the cellular immune response in primary and secondary disorders of immune system and in drug-induced immunodeficiency diseases. Ribotan stimulates production of antibodies against specific antigens as well as interferon and lymphokines synthesis. Ribotan has a bioregulatory activity influencing the functional status of the liver monooxygenase system. Biological effects of Ronkoleikin are directed at growth, definition and activation of T- and B-lymphocytes, synthesis of different isotypes of immunoglobulins in plasma cells, production of interfe-rons α, β, γ. Pilot injections of Polyoxidonium prevent negative effects of the anthelmintic drug on the functional activity of T- and B-lymphocytes and stabilize the immune system.
Keywords: immunity, helminthosis, immunomodulators, therapy.

© 2015 The Author(s). Published by All-Russian Scientific Research Institute of  Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin. 
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI)) and the Agreemnt of 12/06/2014 (CABI org / Human Sciences section)