Russian Journal of Parasitology
DOI:10.12737/13279
Article history:
Received 01.07.2014
Accepted 19.04.2015
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EMBRYOTROPIC PROPERTIES OF A NEW COMPOSITION OF FENBENDAZOLE AND ALBENDAZOLE (PANAVERM PLUS)
Bittirov A. M.1, Begiev S. J.1, Bittirova A. A.1, Kabardiev S. Sh.2, Eldarova L. H.2,
Musayev Z. G.2
1Kabardino-Balkaria State Agrarian University named after V.M. Kokov, 360030, Russia, Kabardino-Balkaria Republic, Nalchik, 9/68 Vatutin St., e-mail: bam_58@mail.ru
2Prikaspiisk Zonal Scientific Research Veterinary Institute, Russia, Republic of Dagestan, Makhachkala, 88 Dahadaev St. , e-mail: pznivi05@mail.ru
Abstract
The drug Panaverm plus administered at the doses of 10,0; 15,0; 25,0; 35,0 and 45,0 mg/kg body weight (by 4.5 times increased dose) showed no embryotropic activity. Panaverm plus used at the dose of 55,0 mg / kg body weight did not cause changes in the development of embryos, except one case of hydrocephaly and reduction of embryo weight.
Objective of research: studies of the embryotropic properties of preparation Panaverm plus.
Materials and methods: The studies of embryotropic properties of preparation Panaverm plus were conducted on 40 outbreed white female rats with weight 200-250 g. in accordance with «Methodical recommendations for estimation of drug effects on reproductive function of animals» approved by Ministry of Healthcare of the Russian Federation (1997).
Results and conclusion: Panaverm plus administered at the doses of 10,0; 15,0; 25,0; 35,0 and 45,0 mg/kg body weight (by 4.5 times increased dose) showed no embryotropic activity. Panaverm plus used at the dose of 55,0 mg / kg body weight did not cause changes in the development of embryos, except one case of hydrocephaly and reduction of embryo weight.
Keywords: embryotropic properties, new composition, fenbendazole, albendazole, Panаverm plus, biosafety, embryotropic properties, toxicity, teratogenicity, mutagenicity.
References
1. Khabriev R. U. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniju novyh farmakologicheskih veshchestv [Handbook for experimental (pre-clinical) studies of new pharmacological compounds]. Moscow, 2005, 68 p.
2. Methodical recommendations for pre-clinical studies of reproductive toxicity of pharmacological preparations. Vedomosti Farmakologicheskogo Komiteta [Bulletin of Pharmacological Committee], 1998, no. 5, pp.13–20.
© 2015 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) and the Agreement of 12.06.2014 (CABI.org / Human Sciences section).