Oxidative stress and change of contents of microcells in embryos tissues at experimental trichinellosis

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OXIDATIVE STRESS AND CHANGE OF CONTENTS OF MICROCELLS IN EMBRYOS TISSUES AT EXPERIMENTAL TRICHINELLOSIS

K.S. Pashinskaya

Trichinellosis is accompanied by oxidative stress in cages of embryos of females of rats which is characterized by increase of level of diene conjugates on 63,12 % and malondialdehyde on 71,32 % and as decrease in activity of catalase on 46,62 %, superoxide dismutase on 36,47 %. In tissues of their embryos has shown decrease in the maintenance of vitamins and reduction of concentration of microelements. Therapy of experimental trichinellosis by one anthelmintic (albendazole or mebendazole) does not lead to normalisation of levels of vitamins and minerals in tissues of embryos. Application for complex therapy experimental trichinellosis of pregnant females of rats of a complex of vitamins of antioxidatic character with selenium will neutralize a disbalance of vitamins and minerals in tissues of embryos and negative action reactive oxygen species.

Keywords: Trichinella spiralis, embryos, oxidative stress, vitamins, microcells, complex therapy.


© 2016 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) and the Agreement of 12.06.2014 (CABI.org / Human Sciences section).