Anthelmintic efficiency of medicinal forms of albendazole received on mechanochemical technologies and use of address delivery Drug Delivery System on laboratory model

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ANTHELMINTIC EFFICIENCY OF MEDICINAL FORMS OF ALBENDAZOLE RECEIVED ON MECHANOCHEMICAL TECHNOLOGIES AND USE OF ADDRESS DELIVERY DRUG DELIVERY SYSTEM ON LABORATORY MODEL

I.I. Glamazdin, I.A. Arkhipov, I.M. Odoevskaja, N.V. Hiljuta, S.S. Halikov, J.S. Chistjachenko, A.V. Dushkin

The efficiency of various forms of albendazole prepared on mechanochemical technologies with use of address delivery DDS (Drug Delivery System) is tested on white mice experimentally infected with Trichinella spiralis in a doze of 250 larvae and Hymenolepis nana in a doze of 200 eggs. The form № 2 in a doze of 10 mg/kg has shown 100% efficiency against T. spiralis and H. nana. Albendazole in the same doze has shown respectively 73,1 and 10,1% effect.

Keywords: Trichinella spiralis, Hymenolepis nana, experimental infection, efficiency, albendazole, mechanochemical technology.


© 2016 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) and the Agreement of 12.06.2014 (CABI.org / Human Sciences section).