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Subacute toxicity of the injective anthelmintic drug Ritril
E.N. Glazyev
postgraduate
I.A. Arkhipov
doctor of veterinary sciences
N.B. Yemelyanova, A.B. Balyshev
PhD in biological sciences
All-Russian Scientific Research Institute of Helminthology
named after K.I. Skryabin, 117218, Moscow, B. Cheremushkinskaya st., 28,
e-mail: arkhipov@vniigis.ru
Subacute toxicity of the injective anthelmintic drug Ritril containing in 1 ml 50 mg ricobendazole and 50 mg triclabendazole has been studied on rats. The medication applied by intramuscular injection at the doses of 40 and 100 mg/kg did not have any effect within 7 days on clinical status, consumption of food and water, hematological and biochemical values, mass coefficients of the organs and functional status of the examined animals. Verifiable changes of estimated values have been registered within 7 days by intramuscular injection of Ritril at a dose of 200 mg/kg. Change in relative liver and lungs weight, decrease of amount of erythrocytes and hemoglobin in rat’s blood, verifiable change of liver values: total and direct bilirubin levels, amounts of aspartate aminotransferase and alanine aminotransferase, and increase of blood urea concentration in rats are determined.
Keywords: Ritril, Ricobendazole, toxic properties, rats, biochemistry, hematology