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Immunotoxic properties of 5 % suspension of Kokcidon
D.S. Poselov
postgraduate
M.V. Arisov
doctor of veterinary sciences
All-Russian Scientific Research Institute of Helmintology named after K.I. Skryabin, 117218, Moscow, B. Cheremushkinskaya st., 28, e-mail: arisov@vniigis.ru
Immunotoxic properties of 5 % suspension of kokcidon in two tests are studied. By results of reaction of hypersensitivity of the slowed-down type the reaction index at the animals receiving a preparation in a therapeutic dose of 0,4 ml/kg, has made 11,46, at the animals receiving a 10 times increased dose – 11,31, and at animals of control group – 14,26 that allows to draw a conclusion on lack of oppressing effect of 5 % suspension kokcidon on the T-cellular link of immune system. A single skin application of tested drug in a therapeutic and tenfold increased therapeutic doses doesn't cause changes of intensity of antibody production against a thymus-dependent antigen. The index of action of a preparation in both doses made 0,98. Reaction of gemagglyutination didn't reveal negative influence of a preparation on the humoral immune answer.
Keywords: immunotoxicity, kokcidon, immunity, hypersensitivity, gemagglyutination, mice, reaction.