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Subacute toxicity of ricazol as injection
E.V. Abramova
postgraduate
I.A. Arkhipov
doctor of veterinary sciences
A.V. Balyshev
PhD in biologic sciences
All-Russian Scientific Research Institute of Helminthology
named after K.I. Skryabin
117218, Moscow, B. Cheremushkinskaya st., 28, e-mail: arkhipov@vniigis.ru
E.V. Glukhareva
International research center «OZOS», Moscow, e-mail: cozos@mail.ru
S. V. Novikova
PhD in biologic sciences
«Nita-Farm», Saratov, e-mail: sr-center@nita-farm.ru
Subacute toxicity of Ricazol as injection, containing in 1 ml 100 mg Rico-bendazole is studied. The preparation in doses of 125 and 50 mg/kg at daily introduction during 7 days didn't cause deviations in behavior, consumption of forage and water, hematologic and biochemical indicators, mass coefficients of bodies, a functional condition of rats. Introduction Ricazol in a dose of 250 mg/kg reduced additional weights and body weight, caused oppression of animals and a case, changes of the main hematologic and biochemical indicators, including erythrocytes, leukocytes, hemoglobin, bilirubin, urea and activity alanine aminotransferase. The dose of ricazol of 250 mg/kg is toxic.
Keywords: Ricazol, Ricobendazole, toxic properties, rats, biochemistry, hematology.