Link t full russian text
Download PDF format
Acute toxicity of ricazol administered as injection
E.V. Abramova
postgraduate
I.A. Arkhipov
doctor of veterinary sciences
All-Russian Scientific Research Institute of Helminthology
named after K.I. Skryabin, 117218, Moscow, B. Cheremushkinskaya st., 28,
e-mail: arkhipov@vniigis.ru
Acute toxicity of Ricazol based on Ricobendazole by oral administration and intramuscular injection in white outbread mice and rats as well as by dermal ad-ministration in white rats is studied. To test the parameters of acute oral toxicity of Ricazol the compound was administered singly to experimental animals (at various doses). General well-being and behavior of animals, manifestation of intoxication symptoms and possible death of animals were observed within 14 days. Post-mortem examination of dead animals was carried out. To investigate acute skin toxicity of Ricazol the compound was given singly to experimental animals on the skin area (size 5cm × 5cm) at the doses of 10000, 15000 и 20000 mg/kg of active ingredient. LD50 value by injection into the stomach for mice was 10000 mg/kg, for male rats – 2500, female rats – 2700 mg/kg. LD50 by dermal administration in rats was 11200 mg/kg, by intramuscular injection in rats – 2500, in male mice – 4900 mg/kg.
Keywords: Ricazol, Ricobendazole, acute toxicity, white mice, rats, LD50.