Cumulative properties of new domestic anthelmintic preparation nadinate

Link t full russian text
Download PDF format


S. A. Kozlov postgraduate 
research advisor - M. B. Musaev doctor of veterinary sciences
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin, 117218, Moscow, 28 Bol. Cheremushkinskaya str., email:

Cumulative properties of a new domestic anthelmintic nadinate as well as its effect on cestodes and nematodes have been studied. The experiments have been performed in white mongrel male rats which were injected with a nadinate suspension prepared on the base of 1 % starch mucilage. Nadinat appointed in the first four days in a dose of 500,7 mg/kg and then every four days 1,5 times to 50 % death of animals. By injection of nadinate into the rats stomachs the cumulative coefficient was 3,2 over 28 days what is the evidence of absence of cumulative properties.

Keywords: nadinate, cumulative properties, rats.


1. Gosudarstvennaja farmakopeja. T. H1, Vyp.2. – M., 1968 – S. 182.
2. Kozlov, S. A. Ostraja toksichnost' nadinata / S. A. Kozlov, M. B. Musaev i dr. // Ros. parazitol. zhurnal. – 2013. – № 2. – S. 120–122.
3. Kozlov, S. A. Antigel'mintnaja jeffektivnost' i terapevticheskie dozy innovacionnogo otechestvennogo antigel'mintika nadinat pri moniezioze ovec / S. A. Kozlov, M. B. Musaev, F. S. Mihajlicyn, A. Ju. Malahova, D. P. Sevbo // Med. parazitol. i parazit. bol. – 2014. – Vyp. 36, № 2. – S. 47–49.
4. Metodicheskie ukazanija po gigienicheskoj ocenke novyh pesticidov. – Kiev, 1988. – S. 32–35.
5. Mihajlicyn, F. S. Poluchenie opytnogo obrazca antigel'mintika nadinata (MST-02) i ocenka ego lechebnoj jeffektivnosti pri moniezioze i strongiljatozah ovec / F. S. Mihajlicyn, D. P. Sevbo, S. N. Trusov i dr. // Med. parazitol. i parazit. bol. – 2011. – № 2. – S. 41.
6. Pravila laboratornoj praktiki v Rossijskoj Federacii: [Prikaz ministerstva zdravoohranenija RF, № 708n ot 23.08.2010 g.].
7. Rukovodstvo po jeksperimental'nomu (doklinicheskomu) izucheniju novyh farmakologicheskih veshhestv / pod red. R. U. Habrieva. – Moskva: Medicina, 2005.
8. Lim, R.R. A method for the walecation of cumulation and subchronic median effective doss / R. R. Lim, K. J. Rink, H. J. Hass, E. Soage–Echague  // Arch. Int. Рharmacodyn. – 1961. – V. 130. – P. 335–353.

© 2016 The Author(s). Published by All-Russian Scientific Research Institute of  Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin.
This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI)) and the Agreemnt of 12/06/2014 (CABI org / Human Sciences section)