The results of the use of the drug Troncil in the treatment of giardiasis in dogs.

Russian Journal of Parasitology, 2016, V.36, Iss.2
DOI: …………………
Received: 22.11.2015
Accepted: 06.04.2016


I.A.Prokhorova V. E. Abramov
1   Independent non-profit organization «Diagnostic and Prevention Research Institute for Human and Animal Diseases» (DPRI),
2  FSBSI« All-Russian Scientific Institute of Fundamental and Applied
Parasitology Animal and Plants named after K.I. Skryabin», 117218,
Moscow, 28, B. Cheremushkinskaya St., Tel (499) 124-56-55,


Objective of research: to study the therapeutic efficiency of domestic anthelmintic drug Troncil in the form of tablets for the treatment of giardiasis in dogs. The analysis of literature sources on the prevalence of giardiasis in humans, dogs and cats in the RF and abroad as well as recommended medications are presented in this article; test results of the domestic anthelmintic drug Troncil for giardiasis in dogs are provided.

Materials and methods: Stool specimens from 20 dogs of a dog shelter were examined; Giardia spp. cysts were detected in fecal samples with the use of PCR- diagnostics.

For this purpose, we used the test system of the laboratory ISOGEN GenPak DNA PCR to detect DNA of Giardia in biological samples from humans and animals using the polymerase chain reaction. PCR product was visualized by agarose gel electrophoresis using ethidium bromide staining, under UV light with a wavelength of 320 nm. The specific amplification fragment of a certain size allows us to presume the presence of DNA of the pathogen in the test sample. The combination anthelmintic Troncil was given within 3 days at a dose of one tablet to dogs

The combination tablets were administered within 3 consecutive days to dogs infected with Giardia lamblia in a quantity of 1 tablet / 10 kg bodyweight per day.

Results and conclusion: High effectiveness of treatment for giardiasis was registered; the excretion of Giardia cysts by infected animals has stopped.

One of the main advantages of the drug Troncil is its high efficiency in comparison with the drug Metronidazole.

The drug Troncil has provided a greater degree of security. There are no known contraindications for the drug Troncil. It may be given to puppies even from 6 weeks of age.

The treatment with the drug Troncil may prove to be a very useful diagnostic tool because it is often used to exclude the diagnosis of helminthiasis and giardiasis in dogs with chronic diarrhea. 3- day course of treatment is usually enough.

Keywords: dogs, children, giardiasis, diagnostics, anti-parasitic drug, treatment, effectiveness.


1.           Avdyuhina T.I., Konstantinova T.N., Kucherya T.V., Gorbunova Yu.P. Lyamblioz. Uchebnoe posobie. Rossiyskaya meditsinskaya akademiya poslediplomnogo obrazovaniya [Giardiasis. Textbook. Russian Medical Academy of Postgraduate Education Studies]. M., 2003.  34 p. (In Russian).

2.           Bouman D., Liotta G. Therapy of symptomatic giardiasis in dogs. Rossiyskiy veterinarny zhurnal. Melkie domashnie zhivotnye. [Russian Journal of Veterinary. Small domestic animals]. M., Kolos, 2010, no. 2, pp. 48 - 49. (In Russian).

3.           Avdyuhina T.I. Lyamblioz. Klinicheskaya parazitologiya. [Giardiasis. Clinical Parasitology]. Geneva, WHO, 2002. Chapter 18, pp. 231 - 240. (In Russian).

4.           Potapenko A.Ya. Giardiasis. Malaya meditsinskaja entsiklopediya v 6 t. [Small Medical Encyclopedia in 6 volumes]. M., Medical Encyclopedia, 1991- 96, vol. 3, pp. 158- 159. (In Russian).

5.           Solov'yov M.M. Biology of lamblia and host-parasite relationship (literature review).  Meditsinskaya parazitologiya i parazitarnye bolezni [Medical Parasitology and Parasitic Diseases], 1968, no. 6, pp. 720-726. (In Russian).

6.           Solov'yov M.M. Stroenie i biologija lyamblij, ih vzaimootnosheniya s organizmom hozyaina. Aftoref. dis. d-ra biol. nauk. [Structure and biology of lamblia, their relationships with the host organism. Abst. doct. diss... biol. sci.]. M., 1973. 42 p. (In Russian).

7.           Telyatnikova N.V., Vershinin I.I. Cystoisosporiasis, giardiasis, and amebiasis in dogs and cats.  Veterinarnaya klinika [Veterinary Clinic]. Yekaterinburg, Uralbioinvest Consulting Ltd., 2005, no.1, pp. 2 - 3. (In Russian).

8.         Shkarenko A.V. Lyamblioz u sobak  [Giardiasis in dogs]. Available at: (accessed 12 January 2015).  (In Russian).

9.           Barr S.C, Bowman D.D, Frongillo M.F., Joseph S.L. Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. Am. J. Vet.. Res., 1998, 59 (9), pp. 1134-1136.

10.         Barutzki D., Schimmel A., Schaper R. Efficacy of pyrantel embonate, febantel and praziquantel against Giardia spp. in naturally infected dogs. Giardia: the cosmopolitan parasite. Leverkusen, Germany, 2002, pp. 177 - 180.

11.         Bowman D., Liotta J., Ulrich M., Charles S., Heine J., Schaper R. Treatment of naturally occurring, asymptomatic Giardia sp. in dogs with Drontal Plus flavour tablets. Parasitol. Res., 2009, Suppl. 1, vol. 105, pp. 125-134.

12.         Merle E., Olson M.E., Heine J. Synergistic effect of febantel and pyrantel embonate in eliminatin of Giardia in a gerbil model. Parasitol. Res., 2009, Aug; 105 Suppl. 1, pp. 135-140.

13.         Montoya A., Dado D., Mateo M., Espinosa C., Miro G. Efficacy of Drontal Flavour Plus (50 mg praziquatel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp. in naturally infected dogs. Parasitol. Res., 2008, vol. 03 (5), pp. l 141-1144.

14.         Payene P., Dryden M., Ridley R., et al. Evaluation of the efficacy of Drontal Plus and Giardia Vax to eliminate cysts shedding in dogs naturally infected with Giardia spp. JAWA. J. Am. Vet. Med. Assoc., 2002, vol. 220 (3), pp. 330-333.

© 2016 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin. This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) and the Agreement of 12.06.2014 ( Sciences section: