DOI
Received 10.04.2016
Accepted 28.11.2016
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Arisov M.V., Glamazdin I.G., Dyomin A.I., Artemov V.V. Tolerability research of complex antiparasitic preparation «Inspector collar» // Russian Journal of Parasitology, M., 2016, V. 38, Iss. 4, pp.
INVESTIGATION OF TOLERABILITY OF COMPLEX ANTIPARASITIC DRUG «INSPECTOR COLLAR»
Arisov M. V.1, Glamazdin I. G.2, Dyomin A. I.2, Artemov V. V.31 The All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin 117218 Moscow,
28 B. Cheremushkinskaya St., tel./fax 8-499-124-56-55, email: arisov_vet@mail.ru
2 FGBOU VPO Moscow State University of Food Production 125080 Moscow, 11, Volokolamsk Highway, e-mail: tyomabullet@yandex.ru
3 Veterinary shelter “Bano Eco”, Moscow.
Abstract
Objective of research: To evaluate the tolerability of the drug, "Inspector Collar" based on Fipronil, Pyriproxyfen and Ivermectin in dogs and cats applied at a therapeutic dose and double increased therapeutic doses.
Materials and methods: Research was conducted at the shelter for dogs and cats «Bano Eco» (Moscow). Effect of drug "Inspector Collar" was studied on 15 clinically healthy outbreed dogs between 2 and 6 years with the body mass of 10–14 kg and 15 clinically healthy outbreed cats between 2 and 4 years with the body mass of 2–3,5 kg, receiving complete and balanced nutrition. Animals were divided into six groups (three groups of dogs and three of cats) five animals in each group. Dogs and cats from the first experimental group had put on one collar (equivalent of single therapeutic dose) for 45 days. The second experimental group had put two collars (double therapeutic dose) for 45 days. Animals from the third (control) group did not carry collars. During the experiment, daily supervision of animals was conducted; their general health status, behavior, appetite were observed, body mass and temperature estimated. Before and 15 and 30 days after the beginning of drug application, blood and urine tests were performed to study morphological and biochemical parameters. Statistical processing of data were carried out using Student's t-test.
Results and discussion: The research results showed that the drug "Inspector Collar" is well tolerated even at double therapeutic dose. All observed indicators remained within the physiological norm.
Keywords: Inspector; collar; dogs; cats; portability; ivermectin; pyriproxyfen; fipronil, hematology, biochemistry.
References
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2. Arisov M. V., Indyukhova E. N. Clinical research of insecticidal and acaricidal activities of «RolfClub 3D collars for dogs». Nauchno-prakticheskiy zhurnal «Veterinariya, zootehniya i biotehnologiya» [Sci. J. «Veterinary, zootechnics and biotechnology»], M., 2014, no. 8, pp. 56–59.
3. Stepanov A. A., Arisov M. V. Toxicological evaluation of insecticidal and acaricidal drug Insacar for arachnoentomoses of carnivores. Rossiyskiy parazitologicheskiy zhurnal [Russian Journal of Parasitology], 2012, no.1, pp. 98–103.
© 2016 The Author(s). Published by All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. Skryabin. This is an open access article under the Agreement of 02.07.2014 (Russian Science Citation Index (RSCI) http://elibrary.ru/projects/citation/cit_index.asp) and the Agreement of 12.06.2014 (CA-BI.org/Human Sciences section: http://www.cabi.org/Uploads/CABI/publishing/fulltext-products/cabi-fulltext-material-from-journals-b...)