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Russian Journal of Parasitology, 2017, V.40, Iss.2
Received: 26.09.2016
Accepted: 10.03.2017
ANTHELMINTIC EFFICIENCY OF NEW PHENASAL FORMULATIONS BASED ON SUPRAMOLECULAR, NANOSCALE DRUG DELIVERY SYSTEMS FOR ANOPLOCEPHALIDOSIS IN HORSES
Limova Yu. B.1, Sadov K. M.1, Korogodina E. V.1, Arkhipov I. A.2, Halikov S. S. 3
1 Samara Research Veterinary Station, 443013, Samara, Magnitogorskaya St., 8, e-mail: samnivs@mail.ru
2 All-Russian Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin, 117218, Moscow, B. Cheremushkinskaya St., 28, e-mail: arkhipov@vniigis.ru
3 A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences. (INEOS RAS). 28, Vavilova St., Moscow, Russia, e-mail: salavatkhalikov@mail.ru
Abstract
Objective of research: Evaluation of efficacy of the new phenasal formulation based on supramolecular, nanoscale Drug Delivery Systems for anoplocephalidosis in horses.
Materials and methods. Research was conducted on 60 horses, spontaneously infected with Anoplocephala spp. Animals were divided in 5 experimental and one control group, up to 10 heads in each. Horses from different groups received orally samples of supramolecular complex of phenasal with various polymers, including polyvinylpyrrolidone (PVP), arabinogalactan in the ratio 1: 2, and silicon dioxide in the ratio 1: 5 at a dose of 20 mg a. i. /kg.
The basic preparation phenasal at a dose of 100 mg/kg was given to horses of the fifth group. Animals that did not receive the drug served as controls. The efficacy of preparations was estimated in control experiment according to the results of coproscopy using the flotation method before and 14 days after treatment.
Results and discussion. 100 % efficacy of supramolecular complex of phenasal with arabinogalactan in the ratio 1: 2 at a dose of 20 mg a.i./kg and basic phenasal at a dose of 100 mg/kg was determined.
Efficiency of phenasal complexes with PVP in the ratio 1: 2 and rabinogalactan in the ratio 1: 5 at a dose of 20 mg a.i./kg at a dose of 20 mg a.i./kg against anoplocephalidosis in horses was 87,2 and 80,1%, respectively.
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