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All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”



Avertel for treatment and prevention of arachno-entomoses, nematodoses and cestodoses in dogs and cats



Avertel is the antiparasitic injectable agent based on aversectin C1 (0,5%) from the class of macrocyclic lactones and praziquantel (5%) from the class of isoquinolines.

The agent has a broad spectrum of antiparasitic action at all life cycle stages of nematodes and tape helminths including Toxocara canis, Toxocara cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Dirofilaria immitis, Dirofilaria repens, Echinococcus granulosus, Echinococcus multilocularis, Taenia spp., Dipylidium caninum, Mesocestoides lineatus, Multiceps multiceps, mites Sarcoptes spp., Notoedres spp., Otodectes cynotis and insects Ctenocephalides felis, Linognathus spp., Trichodectes canis, parasites in dogs and cats.

The mode of aversectin C1 action is its impact on chloride ion current across the membranes of nerve and muscle cells of a parasite. The main targets are avermectin-sensitive glutamate-gated chloride channels and receptors of the gamma-aminobutyric acid. Alteration the chloride ion current results in disturbance the nerve impulses what leads to paralysis and death of a parasite.

The mode of praziquantel action is depolarization of neuromuscular ganglioblocators, impairment of glucose transport and disturbance of microtubule function in cestodes what leads to disruption of muscle innervation and finely to paralysis and death of a parasite.

Aversectin C1 and praziquantel rapidly absorb post subcutaneous administration and distribute in organs and tissues of an animal. Aversectin C1 maximum concentration occurs in the blood on 24 hours following injection. Aversectin C1 predominantly excretes with feces mostly in unchanged form and partially with the urine. Praziquantel maximum concentration is observed in blood on 1 hour post administration. Praziquantel excretes mainly with urine predominantly in the form of metabolites.

Avertel refers to moderately hazardous substances (3 class according to GOST 12.1.007-76); it doesn’t exhibit embryotoxic, teratogenic and mutagenic effects.

Avertel is indicated for dogs and cats as a therapeutic and prophylactic agent at nematodoses (Toxocara canis, Toxocara cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Dirofilaria immitis, Dirofilaria repens infections), cestodoses (Echinococcus granulosus, Echinococcus multilocularis, Taenia spp., Dipylidium caninum, Mesocestoides lineatus, Multiceps multiceps infections), arachnoses (Sarcoptes spp., Notoedres spp., Otodectes cynotis infections) and entomoses (Ctenocephalides felis, Linognathus spp., Trichodectes canis infections).

The individual increased sensitivity of animals is the contraindication to application of Avertel.

Due to the high sensitivity of dogs of some breeds to avermectins agent should not be applied in dogs of the following breeds: collie, sheltie and bobtail.

Avertel is administered to the animals subcutaneously once in a nape region in a volume of 1 ml per 10 kg of body weight.

At nematodes, cestodoses and entomoses Avertel is used once, at  arachnoses - twice with 7-10 day interval. At acaroses clinical recovery of animals is confirmed by two negative analyses of scrapings taken from skin or ear.

In order to prevent reinfection by fleas one should replace animal’s bedding or treat it by insecticides in accordance with the recommended instructions for application.

At agent’s overdosing the following signs may occur: swelling at the injection site, loss of coordination, recumbency. The specific agents of detoxification are absent; one should apply common measures aimed on elimination of the drug.

The specific features of agent’s action at its first application or withdrawal are not revealed.

One should not treat pregnant and lactating females as well as puppies and kittens younger 2-month age.

Side effects and complications in animals are generally not observed at application of Avertel following the above recommendations. In case of allergic reactions one should stop application and administer to an animal antihistamines and symptomatic agents.

Avertel should not be used simultaneously with the preparations based on avermectins and should not be mixed in the same syringe with other agents.

Avertel is not intended for the treatment of productive animals.

When working with Avertel one should comply with the general rules of hygiene and safety recommended for dealing with drugs. The treatment of animals should be carried out in rubber gloves. While working with the product it is not allowed to smoke, drink and eat. Post work with an agent one should wash hands with warm water and soap.

In case of accidental contact of the agent with skin one should immediately wash off it with water and soap; in case of eye contact rinse them for several minutes under running water. In case of allergic reactions or accidental ingestion of agent one should immediately contact with medical facility (you should have the instructions for agent’s application or label).

Do not use empty containers for the agent for domestic purposes. They must be placed into a plastic bag and utilized with household waste.

Link to the article "Estimation of efficacy of antiparasitic drug avertel against endo- and ectoparasites in dogs and cats - Yastreb V.B., Novik T.S." in the section Publications:
Russian Journal of Parasitology - Issue 2014 - 4 quarters
Link to full russian text